Exposure to vinyl chloride monomer: report on a cohort study.

Worker exposure to vinyl chloride and poly(vinyl chloride).

The National Institute for Occupational Safety and Health (NIOSH) in early 1974 began industrial hygiene studies of vinyl chloride exposed workers. Three VC monomer plants, three VC polymerization plants, and seven PVC fabrication plants were surveyed. V polymerization plant workers and workers in one job category in VC monomer plants were exposed to average levels above 1 ppm. The highest aver...

Results of sputum, cytology among workers exposed to vinyl chloride monomer and to poly(vinyl chloride).

The results of systematic cytological sputum examinations of 3,380 Italian VC-PVC industry workers and of 2,287 workers in other industries at different potential risk and chosen as control groups are reported. The results indicate an increase in cellular abnormalities and dysplasias in the epithelium of the respiratory tract among VC-PVC workers. These data are in line with experimental result...

Persistent Raynaud's phenomenon after exposure to vinyl chloride monomer: assessment of endothelial damage.

Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer.

Various malignant tumors of the liver, especially liver angiosarcoma, have been described after occupational exposure to vinyl chloride monomer. We present the case records and pathologic findings of two plastic industry workers who had been exposed to high concentrations of vinyl chloride. These workers developed hepatic neoplasms, angiosarcoma, or hemangiopericytoma. We discuss the histogenes...

Risk Assessment of Exposure to Vinyl Chloride

Carcinogenic risk estimation of human exposure to vinyl chloride (VC) was determined by utilizing laboratory animal data on the chronic bioassay of VC, VC pharmacokinetics and VC macromolecular interaction. The impact of these data upon the type of risk VC may pose to humans and the selection of appropriate mathematical models to quantitatively estimate "risk" are discussed. The problem of esti...